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CAS
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556-27-4
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中文名称
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蒜氨酸
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英文名称
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Alliin
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别名
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S-allyl cysteine sulfoxide;ACSO;3-(Allylsulphinyl)-L-alanine;(S)-3-(Allylsulphinyl)-L-alanine
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纯度
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HPLC≥98%
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分子式
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C6H11NO3S
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分子量
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177.22
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外观（性状）
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White to off-white Solid
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储存条件
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Powder : -20℃, 2 years;In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO
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MDL
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MFCD01311056
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EC
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Einecs 209-118-9
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InChIKey
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XUHLIQGRKRUKPH-ITZCMCNPSA-N
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InChI
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InChI=1S/C6H11NO3S/c1-2-3-11(10)4-5(7)6(8)9/h2,5H,1,3-4,7H2,(H,8,9)/t5-,11?/m0/s1
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PubChem CID
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87310
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SMILES
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N[C@@H](C[S@](CC=C)=O)C(O)=O
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描述
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是一类大蒜中独特的非蛋白类含硫氨基酸。(It is a unique non-protein sulfur-containing amino acid in a class of garlic.)
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靶点
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Others
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通路
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Others
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生物活性
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Alliin， the most abundant sulphur compound in garlic， has been demonstrated to exhibit hypoglycemic， antioxidant and anti-inflammatory activities. Alliin was effective on attenuating 1，3-DCP-induced lipogenesis via activation of the AMPK-SREBPs signaling pathway in HepG2 cells.[1]
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In Vitro
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Alliin attenuated lipogenesis induced by 1，3-DCP and that the reduction was due to activation of the AMPK pathway. HepG2 cells exposed to 1，3-DCP exhibited significant increase of triglyceride(TG) and total cholesterol(TC)， and alliin reduced the accumulation. Most importantly， alliin could up-regulate the phosphorylation of AMPK and down-regulate protein and gene expressions of SREBP-1; FAS; SREBP-2;HMGCR in 1，3-DCP-induced HepG2 cells. [1]
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In Vivo
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Alliin ameliorates DSS-induced ulcerative colitis and inhibits the inflammatory responses in LPS-stimulated RAW264.7 cells partly through inhibiting ERK1/2-， JNK-/PPAR-γ-stimulated NF-κB/AP-1/STAT-1 activations.[2]
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动物实验
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The phenotype of mice was recorded in the DSS-induced and/or alliin (500 mg/kg) groups. Histopathological alterations were analyzed by H&E staining. MPO and MDA of colon tissues were measured. The mRNA expression levels of inflammatory factors were determined by qRT-PCR， and protein expressions of inflammatory factors or activation of kinases were determined by Western blotting.[2]
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数据来源文献
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[1]. Lu J， et al. Alliin attenuates 1， 3-dichloro-2-propanol-induced lipogenesis in HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway. Life Sci. 2018 Feb 15;195:19-24.
[2]. Shi L， et al. Alliin， a garlic organosulfur compound， ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation. Mol Nutr Food Res. 2017 Sep;61(9).
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规格
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5mg 10mg 20mg
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单位
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支
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