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CAS
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7424-00-2
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中文名称
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DL-4-氯苯丙氨酸
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英文名称
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4-Chloro-DL-phenylalanine
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别名
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DL-4-Chlorophenylalanine;CP-10188;PCPA;Fenchlonine;芬克洛宁
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纯度
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≥98%
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分子式
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C9H10ClNO2
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分子量
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199.63
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外观（性状）
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White to off-white Solid
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储存条件
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Powder : -20℃, 2 years;In solvent(母液): -20℃, 1 month; -80℃, 6 months
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溶解性
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Soluble in DMSO ≥5mg/mL(Need ultrasonic or Water bath)
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EC
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EINECS 231-051-9
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MDL
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MFCD00002601
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InChIKey
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NIGWMJHCCYYCSF-UHFFFAOYSA-N
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InChI
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InChI=1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
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PubChem CID
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4652
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SMILES
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NC(CC1=CC=C(Cl)C=C1)C(O)=O
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描述
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Fenclonine 是有效的色氨酸羟化酶 (Trp) 的不可逆抑制剂。(Fenclonine is a potent irreversible inhibitor of tryptophan hydroxylase (Trp).)
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靶点
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Tryptophan Hydroxylase
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通路
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Metabolic&Enzyme
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生物活性
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Fenclonine is a selective and irreversible tryptophan hydroxylase inhibitor， which is a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine can be used in carcinoid syndrome research[1-3].
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In Vivo
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Fenclonine (intraperitoneal injection; 100 mg/kg; once daily; 3 d) treatment can inhibit Morphine-induced anti-nociceptive activity[2].Fenclonine (intraperitoneal injection; 300 mg/kg; once daily; 3 d) pretreatment completely abolishes the effects of a 50?mg/kg dose of Paracetamol[3].
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动物实验
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Animal Model: Wistar albino rats of either sex and weighing between 80 and 100 g;Dosage: 100 mg/kg;Administration: Intraperitoneal injection; 100 mg/kg; once daily; 3 days[2]
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数据来源文献
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[1]. M Jouvet. Sleep and serotonin: an unfinished story. Neuropsychopharmacology. 1999 Aug;21(2 Suppl):24S-27S.
[2]. A K Sanyal, et al. Prostaglandins: antinociceptive effect of prostaglandin E1 in the rat. Clin Exp Pharmacol Physiol. 1977 May-Jun;4(3):247-55.
[3]. Shyamshree S S Manna, et al. Paracetamol potentiates the antidepressant-like and anticompulsive-like effects of fluoxetine. Behav Pharmacol. 2015 Apr;26(3):268-81.
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规格
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50mg 10mM*1mL in DMSO 100mg 500mg
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单位
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瓶
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