Astragalus polysaccharide 黄芪多糖-北京杰辉博高生物技术有限公司

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Astragalus polysaccharide 黄芪多糖

品牌：Solarbio

产地：国产

货号：IA0570

发布日期： 2023-06-15
更新日期： 2025-03-25

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产地	国产
品牌	Solarbio
货号	IA0570
用途	科研
包装规格	50mg
CAS编号
纯度	90%
是否进口	否

中文名称	黄芪多糖
英文名称	Astragalus polysaccharide
别名	Astragalus Polysacharin
纯度	UV≥90%
分子式	Mixture
外观（性状）	Yellow to brown Solid
储存条件	Powder : 2-8℃, 2 years
溶解性	Soluble in Water ≥5mg/mL(可能有少量杂质不溶，但并不影响使用/There may be a small amount of impurities that do not dissolve, but it does not affect the use )
描述	由己糖醛酸、葡萄糖、果糖、鼠李糖、阿拉伯糖、半乳糖醛酸和葡萄糖醛酸等组成,可作为免疫促进剂或调节剂,同时具有、抗肿瘤、抗衰老、抗辐射、抗应激、抗氧化等作用。(It is composed of hexuronic acid, glucose, fructose, rhamnose, arabinose, galacturonic acid and glucuronic acid. Anti-stress and antioxidant effects.)
靶点	Others
通路	Others
生物活性	APS can protect the cytotoxicity and genotoxicity of human BMSCs induced by FA. The mechanism may be associated with up-regulated expression of XPA, XPC, ERCC1, RPA1, and RPA2 in the nucleotide excision repair (NER) pathway which promotes DNA damage repair.[1]
In Vitro	Human BMSCs were cultured in vitro and randomly divided into control cells (Ctrl group), FA-treated cells (FA group, 120 μmol/L), and cells incubated with FA and increasing concentrations (40, 100, or 400 μg/mL) of APS (FA + APS groups). Compared with the FA group, the cytotoxicity, DNA strand breakage, DPCs, and micronucleus levels were decreased significantly in FA + APS groups (P < 0.01). Meanwhile, the mRNA and protein expression of XPA, XPC, ERCC1, RPA1, and RPA2 were up regulated significantly in the FA + APS groups (P < 0.05) with the most prominent effect of the 100 μg/mL APS.[1]
数据来源文献	[1] She Y, Zhao X, Wu P, Xue L, Liu Z, Zhu M, Yang J, Li Y. Astragalus polysaccharide protects formaldehyde-induced toxicity by promoting NER pathway in bone marrow mesenchymal stem cells. Folia Histochem Cytobiol. 2021;59(2):124-133.
规格	50mg
单位	瓶

由己糖醛酸、葡萄糖、果糖、鼠李糖、阿拉伯糖、半乳糖醛酸和葡萄糖醛酸等组成，可作为免疫促进剂或调节剂，同时具有、抗肿瘤、抗衰老、抗辐射、抗应激、抗氧化等作用。

使用本产品的案例（仅供参考）

In Vitro

Cell（Human BMSCs ,40~400 μg/mL APS, 24h）

BMSCs were randomly divided into control group, FA group, and FA + APS 40, 100 and 400 μg/mL groups. In the control group, the cells were cultured with D-MEM/F-12. The cells in the FA group were cultured with 120 μmol/L FA of D-MEM/F-12. BMSCs co-cultured with 120 μmol/L FA and 40, 100, 400 μg/mL APS of D-MEM/F-12 served as FA + APS 40, 100 and 400 μg/mL groups. FA and APS were added at the same time and incubated together with BMSCs for 24 h.

来源文献：She Y, Zhao X, Wu P, Xue L, Liu Z, Zhu M, Yang J, Li Y. Astragalus polysaccharide protects formaldehyde-induced toxicity by promoting NER pathway in bone marrow mesenchymal stem cells. Folia Histochem Cytobiol. 2021;59(2):124-133. doi: 10.5603/FHC.a2021.0013. Epub 2021 May 19. PMID: 34008856.